The discovery of new enzymes, the understanding of enzyme structure and function, and the intelligent evolution of enzymes are important scientific and technological foundations for synthetic biology and biomanufacturing technology. Based on the cross-integration of biology and physics, chemistry, information, mathematics and other disciplines, Weiyuan Biotech combines computational biology, artificial intelligence and big data and other technical means to analyze the structure and function relationship of enzyme proteins and develop core algorithms and tools for enzyme molecular design box, to design and construct industrial enzyme catalysts with high activity, high stability and good operational robustness, to improve the catalytic performance and industrial properties of industrial enzyme catalysts, focusing on verification of functionalization reactions such as carbon-hydrogen bonds and carbon-nitrogen bonds. , providing new practical industrial enzyme catalysts for new products and new processes.
How to quickly and effectively extract active ingredients from natural products and further separate and purify the extracts has become a "bottleneck" in natural product research. The bioenzymatic hydrolysis technology developed by Weiyuan Biotechnology has the characteristics of high catalytic efficiency, strong specificity, and mild action conditions. It breaks through the bottleneck of traditional substance extraction technology in the production process and retains biological active substances to the greatest extent. It is expected to be applied In many fields such as medicine, food, and health products.
Cell-free multi-enzyme cascade is a biomanufacturing platform for in vitro synthetic biology, located between microbial fermentation and enzyme molecular catalysis. Multi-enzyme molecular machines are unique biocatalysts for in vitro biotransformation. Based on the principle of simplifying complexity, multiple natural enzymes, artificial enzymes and (biomimetic) coenzymes are used to reconstruct in vitro artificial metabolic pathways, getting rid of the limitations of self-reproduction of organisms and transcending Cell synthesis limits, achieving important biochemical synthesis, efficient and low-cost production of bulk biochemical products, and efficiently reshaping the production potential of the "cell factory".
Tiny steps, towering dreams
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